2026 Week 4 Fantasy Football: Keon Coleman Misses Bills Practice with Ankle Injury

According to ProFootballTalk (NBC Sports), Keon Coleman missed the Bills' first practice of the week on Wednesday, September 30, due to the ankle injury that had him listed as questionable heading into last Sunday's game against the Chargers. Coleman did play that game, but his ramp-up was already restricted — he practiced only on the Friday before kickoff. Missing Wednesday entirely is a step in the wrong direction and raises real availability questions for Week 5.

Also of note: DJ Moore was limited at Wednesday's practice with a shoulder injury. ProFootballTalk did not specify the severity, and no timeline was provided for either Bills receiver.

Keon Coleman

Coleman is trending the wrong way. He gutted through last week on a limited practice schedule, and now he's not practicing at all to open the new week. If this ankle issue keeps him out or limits him again, his fantasy value takes a direct hit. Monitor Thursday's practice report closely — if he's out again, fade him until you see a full or at least limited return to the field.

DJ Moore

Moore's shoulder injury is new information from this report. He was limited Wednesday, which is worth tracking but not yet alarming on its own. The Coleman connection matters here: if Coleman's ankle keeps him sidelined or at reduced capacity, Moore becomes a more attractive target in the Bills' passing game by default. That upside is contingent on Coleman's status, so watch both injury reports together as the week progresses.