2026 Week 4 Fantasy Football: Mike Evans, Christian McCaffrey, KhaDarel Hodge Injury Update

According to ProFootballTalk (NBC Sports), 49ers head coach Kyle Shanahan confirmed Wednesday that wide receiver Mike Evans, running back Christian McCaffrey, and wide receiver KhaDarel Hodge are all sitting out the first practice of Week 4. Evans and Hodge are injured; McCaffrey is resting. The full injury report also includes linebacker Dre Greenlaw, left tackle Trent Williams, defensive end Nick Bosa, and several others — this is a battered roster heading into the week.

Mike Evans

Evans suffered a rib injury in Sunday's win over the Cardinals and is listed as questionable. Shanahan declined to specify whether it's a fracture, saying only "that's about as much as I know. Just rib" — though teammate George Kittle referenced fractured ribs in a separate comment reported by ProFootballTalk. Shanahan said he hopes Evans can practice by the end of the week, which is at least a signal that he's not already ruled out. That's a thin silver lining. Rib injuries are notoriously painful and hard to play through, and with the 49ers' receiver room already decimated — the source data notes San Francisco lost Ricky Pearsall, De'Zhaun Stribling, and Demarcus Robinson to injuries earlier this season — there's real risk Evans is limited or out even if he does return to practice Friday. Treat him as a game-time decision and have a backup plan ready.

KhaDarel Hodge

Hodge (knee) also won't practice Wednesday. He's the direct beneficiary if Evans misses time, but the fact that Hodge himself is banged up undercuts that upside immediately. The 49ers' receiver depth is genuinely thin based on what's been reported, so monitor Hodge's practice status closely — if he clears, he becomes a desperation streamer in deeper leagues. If he doesn't, you're looking at a wideout room that's been gutted by injury all season.

Christian McCaffrey

McCaffrey's absence Wednesday is listed as rest, not injury — no concern here. Shanahan managing a veteran running back's Wednesday practice in Week 4 is standard operating procedure. Unless something changes later in the week, McCaffrey's fantasy outlook is unaffected by today's report.