2026 Week 5 Fantasy Football Breaking News: DJ Moore and Joshua Palmer Both Inactive for Bills on Monday Night Football

According to ProFootballTalk (NBC Sports), Bills wide receiver DJ Moore is inactive for Monday Night Football after aggravating an AC sprain in his left shoulder. Moore has 12 catches for 178 yards and a touchdown on the season — he's the clear WR1 on this offense, and his absence is a significant hit to Buffalo's passing attack tonight.

Also inactive: fellow Bills wide receiver Joshua Palmer, who is out with a shoulder injury of his own. Two starting-caliber wideouts off the board at once forces Buffalo to turn to its practice-squad depth. The Bills elevated Trent Sherfield from the practice squad earlier today, and rookie Skyler Bell is active for the first time this season, per the same report.

DJ Moore

Sit him — he's inactive, full stop. The AC sprain is the concern going forward; the source story doesn't specify a recovery timeline beyond tonight, so don't assume he's back next week without further updates. Dynasty managers should monitor closely, but there's nothing here yet to suggest this is a long-term problem.

Joshua Palmer

Palmer is also inactive (shoulder), compounding the Bills' WR woes. He was already operating behind Moore on the depth chart, but his absence alongside Moore's means there's essentially no established pass-catcher stepping into a big role — it's Bell and Sherfield inheriting whatever targets the Bills can generate. Neither is a reliable fantasy play in standard formats, though Sherfield is the safer speculative add in deeper leagues if you need a Hail Mary tonight.

The connected fantasy angle here is simple: with Moore and Palmer both out, the Bills' QB and tight end become more attractive (more target volume has to go somewhere), and the Rams' pass defense faces a far less threatening receiving corps than expected. Fade Buffalo's WR room entirely tonight.