2026 Week 5 Fantasy Football: Deebo Samuel Ruled Out with Hamstring Injury

San Francisco 49ers wide receiver Deebo Samuel has been ruled out of Sunday's Week 5 game against the Seahawks with a hamstring injury, according to ProFootballTalk (NBC Sports). Samuel hurt himself on a running play, stepping awkwardly trying to get around the corner, then fumbling on the way down — a turnover Seattle cornerback Josh Jobe recovered at the San Francisco 36. The Seahawks converted it into a field goal and now lead 26-21.

Deebo Samuel

Samuel's day ended with two catches for 21 yards and two carries for 4 yards, plus the lost fumble. The hamstring injury — and the awkward nature of the play — is a genuine concern for his availability going forward, though ProFootballTalk does not specify a recovery timeline. If you have Samuel in your lineup today, his day is over. Dynasty managers should monitor this closely; hamstring injuries on skill players can linger.

Jacob Cowing

The bad news compounds in San Francisco: Jacob Cowing is also questionable to return with an ankle injury suffered in the same game, per ProFootballTalk. Cowing had one catch for 9 yards and lost a fumble on a punt return before exiting. With both Samuel and Cowing banged up, ProFootballTalk reports that Mike Evans, Brandin Cooks, and Jordan Watkins are the only healthy 49ers receivers still available. That trio now absorbs all the targets in a game San Francisco is trailing — which is about as clear a usage spike as you'll see mid-week on the waiver wire (the priority list of unclaimed players available for your roster).

Cooks and Watkins all become emergency streamers for anyone in a bye-week or injury bind this week. Next week's implications depend entirely on Samuel's and Cowing's practice statuses, which are not yet known. Keep a close eye on the injury report Wednesday.