2026 Week 5 Fantasy Football: Saquon Barkley, DeVonta Smith, Marquise Brown Eagles Injury Update

Saquon Barkley, DeVonta Smith, and center Drew Kendall missed their second straight Eagles practice Thursday, according to ProFootballTalk (NBC Sports). Official injury designations for Sunday's London game against the Jaguars drop Friday — the same day Philadelphia crosses the Atlantic — so fantasy managers are on a tight clock here.

The situation up front is also a mess. Per the story, Cam Jurgens was traded away this week and Lane Johnson retired, leaving the Eagles with significant offensive line shuffling ahead of an international game. That context matters: even if Barkley plays, he may be running behind a reshuffled line.

Saquon Barkley

Back-to-back missed practices with a hamstring issue is a genuine alarm bell for a running back. Hamstrings are notoriously tricky, and the source story gives no indication he's trending toward playing. Until Friday's designation says otherwise, treat Barkley as a game-time decision at best — and have a handcuff or backup ready. If he's ruled out, his replacement becomes an instant must-start depending on your league's waiver situation.

DeVonta Smith

Smith is in the same boat as Barkley: two missed practices, hamstring, no positive update from the source story. If he can't go Sunday, the Eagles' passing game options thin out quickly — which brings us directly to the next player.

Marquise Brown

Brown is already listed as questionable with an ankle issue and did not practice Thursday either, per ProFootballTalk (NBC Sports). Here's the problem: if both Smith and Brown miss the London game, the Eagles' wide receiver room takes a massive hit simultaneously. Neither player looks safe to start right now. If one or both are ruled out Friday, monitor the depth chart closely — Dontayvion Wicks is limited with a hamstring issue of his own, so even the next man up isn't fully healthy.

Dontayvion Wicks

Wicks was a limited participant Thursday with a hamstring concern. He's only relevant if Smith and/or Brown are ruled out, and even then his own limited status caps confidence. He's a speculative add in deeper leagues, not a plug-and-play solution.

The bottom line: watch Friday's injury report like a hawk. The Eagles are sending a potentially banged-up offense to London with a reshuffled offensive line. Anyone relying on multiple Eagles skill players this week is carrying real risk into the weekend.