2026 Week 6 Eagles Injury Update: Barkley and Smith Both Concerning

According to ProFootballTalk (NBC Sports), the Eagles opened 21-day practice windows for four players on Wednesday — but the real fantasy news out of Philadelphia is more worrying: running back Saquon Barkley was not on the field for the portion of practice open to media, and receiver DeVonta Smith was working out on a side field rather than with the full team. Both players carry a questionable injury designation heading into Week 6.

The official Week 6 injury report hadn't dropped at time of publication, so we don't yet have practice participation designations (limited, full, DNP) to lean on. That context matters — side-field work and absence from media-viewing windows don't always mean a player is trending toward a scratch. But both absences are worth monitoring closely as the week progresses.

Saquon Barkley

Not being on the field at all is the more alarming of the two situations. Barkley is a weekly top-tier fantasy running back, and any genuine doubt about his availability this week is a four-alarm alert. If he's ruled out or limited Sunday, Dameon Pierce becomes a priority add on the waiver wire, so don't act on that front until we know more.

DeVonta Smith

Side-field work typically signals a player managing something but not yet cleared for full team reps. Smith's questionable tag means he's not a safe set-and-forget start this week. In PPR formats (points per reception), Smith's target share makes him a high-stakes call — losing him also concentrates targets elsewhere in the Eagles' passing game, so monitor his status as a tiebreaker for his teammates too. Again, no additional detail on the nature of his injury was provided in the source report.

The connection here is obvious: if both Barkley and Smith miss or are limited, Philadelphia's offense takes a significant hit. Check the Eagles' official injury reports this week to get the latest.