2026 Week 6 Fantasy Football: Deebo Samuel Out, Mike Evans Questionable for 49ers vs. Commanders

The 49ers are heading into Monday night's home game against the Commanders short-handed at wide receiver, according to ProFootballTalk (NBC Sports). Deebo Samuel has been ruled out with a hamstring injury, and Mike Evans (ribs, Achilles) is listed as questionable after not practicing at all this week.

Deebo Samuel

Samuel is out — full stop. If you were counting on him in Week 6, find a replacement now. The hamstring designation with no practice participation this week makes this a clean scratch, not a borderline call. Dynasty managers should monitor how quickly he returns, but the source story gives no recovery timeline.

Mike Evans

Evans didn't practice once this week, so "questionable" here leans toward out rather than a true coin flip. The 49ers are leaving the door open, per ProFootballTalk (NBC Sports), but a rib-and-Achilles combo with zero practice reps is a hard fade in most formats. If you have a viable alternative on your roster, start them. If you're roster-thin and desperate, Evans is a hold-and-monitor situation right up until Monday night's active/inactive report.

With both Samuel and Evans potentially unavailable, Christian Kirk — also listed as questionable with a calf injury — becomes relevant but uncertain himself. The source story does not clarify which, if any, of the questionable receivers practiced this week, so Kirk's true availability is unclear heading into game day. Fullback Kyle Juszczyk does return from his knee injury with no injury designation, which is a minor positive for San Francisco's offense but carries minimal direct fantasy value outside of niche formats.