2026 Week 6 Fantasy Football: Eagles Injury Report Reaction — Barkley, Smith Both DNP

The Eagles listed 24 players on their Wednesday injury report, according to ProFootballTalk (NBC Sports), and none of them were resting veterans — this is a real injury list. The two biggest fantasy names, running back Saquon Barkley (hamstring) and wide receiver DeVonta Smith (hamstring/toe), did not practice at all. Smith also picked up a new toe injury, per the report. Both situations demand close attention before Week 6 lineups lock.

Saquon Barkley

Barkley's DNP with a hamstring is the most alarming line on this report. Hamstrings and the DNP designation early in the week are a bad combination — they're the kind of injury that can go from "day-to-day" to "out" quickly. Will Shipley, who would be the next man up, is listed as doubtful with a foot injury. If both are out, Philadelphia's backfield picture becomes murky. The source story does not specify a timeline or severity for Barkley, so monitor Thursday and Friday practice reports closely before making any lineup decisions.

Will Shipley

Shipley's doubtful tag with a foot injury compounds the Barkley concern — the Eagles could be thin at running back in Week 6. His DNP and doubtful designation suggest he's unlikely to play even if Barkley sits. If you're holding Shipley as a handcuff, don't count on him this week.

DeVonta Smith

Smith didn't practice and is now dealing with both a hamstring issue and a new toe injury. Two active ailments and a DNP is not a good look. Marquise Brown (ankle) was limited — so he's not a clean plug-in replacement either, though he carries a questionable tag rather than a DNP. Dontayvion Wicks was also limited with a hamstring issue, meaning Philly's whole receiver room is banged up. If Smith is out, no single receiver steps into a workhorse role cleanly here.

Marquise Brown

Brown is questionable with an ankle and was limited in practice. If Smith misses Week 6, Brown is the most obvious beneficiary — but his own injury status means you can't count on him without monitoring the final injury report. He's a risky boom-or-bust play this week.

Dontayvion Wicks

Wicks was limited with a hamstring and is worth tracking as a deep-roster flier only if both Smith and Brown are ruled out. Don't rush to add him until the full extent of the Eagles' WR absences is clear.

Jalen Hurts

The good news: Hurts (calf) was a full participant, per the source report. He's not a concern for this week based on Wednesday's practice.

The bottom line: this Eagles injury report is ugly across the skill positions. Check the final injury designations — likely released Friday — before finalizing any Philly player in your lineup.